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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
20.91
Human Site:
S187
Identified Species:
32.86
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
S187
R
R
P
L
N
N
N
S
E
I
A
L
S
L
S
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
S187
R
R
P
L
N
N
N
S
E
I
A
L
S
L
S
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
S187
R
R
P
L
N
N
N
S
E
I
A
L
S
L
S
Dog
Lupus familis
XP_543464
544
61233
S188
R
L
P
L
N
N
N
S
E
I
A
L
S
V
W
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
S191
R
C
P
L
S
N
N
S
E
I
A
L
S
L
C
Rat
Rattus norvegicus
NP_446129
545
60912
S190
R
C
P
L
S
N
N
S
E
I
A
L
S
L
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
F180
T
N
K
V
F
V
F
F
D
L
T
V
D
D
Q
Chicken
Gallus gallus
NP_001073576
522
58779
D184
V
F
S
D
L
T
V
D
D
Q
L
V
F
P
R
Frog
Xenopus laevis
NP_001082016
517
58243
V178
F
V
F
S
D
L
S
V
D
D
Q
T
I
Y
P
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
G105
I
K
A
L
I
G
R
G
S
F
S
R
V
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
P160
F
V
F
K
D
L
S
P
N
E
S
I
G
L
P
Honey Bee
Apis mellifera
XP_624334
480
54300
K163
L
P
P
E
L
K
N
K
Y
T
V
S
R
K
L
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
H160
Y
E
S
A
D
A
D
H
H
P
E
E
L
T
K
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
P163
D
S
D
Q
S
N
L
P
E
A
L
R
E
K
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
Q177
Q
I
S
A
T
S
S
Q
N
A
T
T
S
A
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
100
80
N.A.
80
80
N.A.
0
0
0
6.6
N.A.
6.6
13.3
0
13.3
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
26.6
13.3
20
26.6
N.A.
33.3
13.3
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
14
0
7
0
0
0
14
40
0
0
7
7
% A
% Cys:
0
14
0
0
0
0
0
0
0
0
0
0
0
0
14
% C
% Asp:
7
0
7
7
20
0
7
7
20
7
0
0
7
7
0
% D
% Glu:
0
7
0
7
0
0
0
0
47
7
7
7
7
0
0
% E
% Phe:
14
7
14
0
7
0
7
7
0
7
0
0
7
0
7
% F
% Gly:
0
0
0
0
0
7
0
7
0
0
0
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
7
7
0
0
0
0
0
0
% H
% Ile:
7
7
0
0
7
0
0
0
0
40
0
7
7
0
0
% I
% Lys:
0
7
7
7
0
7
0
7
0
0
0
0
0
14
7
% K
% Leu:
7
7
0
47
14
14
7
0
0
7
14
40
7
40
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
27
47
47
0
14
0
0
0
0
0
0
% N
% Pro:
0
7
47
0
0
0
0
14
0
7
0
0
0
7
14
% P
% Gln:
7
0
0
7
0
0
0
7
0
7
7
0
0
0
7
% Q
% Arg:
40
20
0
0
0
0
7
0
0
0
0
14
7
0
14
% R
% Ser:
0
7
20
7
20
7
20
40
7
0
14
7
47
0
20
% S
% Thr:
7
0
0
0
7
7
0
0
0
7
14
14
0
7
0
% T
% Val:
7
14
0
7
0
7
7
7
0
0
7
14
7
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
7
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _